(Table 1) Concentration of PCB and other contaminants in blood plasma of polar bears (Ursus maritimus) from Svalbard
Citation
Gutleb A C, Cenijn P, van Velzen M, Lie E, Ropstad E, Skaare J U, Malmberg T, Bergman Å, Gabrielsen G W, Legler J (2010). (Table 1) Concentration of PCB and other contaminants in blood plasma of polar bears (Ursus maritimus) from Svalbard. PANGAEA - Data Publisher for Earth & Environmental Science. Occurrence dataset https://doi.org/10.1594/pangaea.810387 accessed via GBIF.org on 2024-09-01.Description
Persistent chemicals accumulate in the arctic environment due to their chemical reactivity and physicochemical properties and polychlorinated biphenyls (PCBs) are the most concentrated pollutant class in polar bears (Ursus maritimus). Metabolism of PCB and polybrominated biphenyl ether (PBDE) flame-retardants alter their toxicological properties and these metabolites are known to interfere with the binding of thyroid hormone (TH) to transthyretin (TTR) in rodents and humans. In polar bear plasma samples no binding of [125I]-T4 to TTR was observed after incubation and PAGE separation. Incubation of the plasma samples with [14C]-4-OH-CB107, a compound with a higher binding affinity to TTR than the endogenous ligand T4 resulted in competitive binding as proven by the appearance of a radio labeled TTR peak in the gel. Plasma incubation with T4 up to 1 mM, a concentration that is not physiologically relevant anymore did not result in any visible competition. These results give evidence that the binding sites on TTR for T4 in wild living polar bears are completely saturated. Such saturation of binding sites can explain observed lowered levels of THs and could lead to contaminant transport into the developing fetus.Taxonomic Coverages
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Animaliarank: kingdom
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Chordatarank: kingdom
Geographic Coverages
Event: Svalbard_bear,
Svalbard
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Bibliographic Citations
Contacts
Arno C Gutleboriginator
Peter Cenijn
originator
Martin van Velzen
originator
Elisabeth Lie
originator
Erik Ropstad
originator
Janneche Utne Skaare
originator
Tina Malmberg
originator
Åke Bergman
originator
Geir W Gabrielsen
originator
Juliette Legler
originator
metadata author
PANGAEA - Data Publisher for Earth & Environmental Science
email: info@pangaea.de
homepage: https://www.pangaea.de
Frank-Oliver Glöckner
administrative point of contact
Robert Huber
administrative point of contact